G9893
Sigma
Gliotoxin from Gliocladium fimbriatum
| CAS Number: | 67-99-2 |
| Linear Formula: | C13H14N2O4S2 |
| Molecular Weight: | 326.39 |
| Beilstein Registry Number: | 50675 |
| MDL number: | MFCD00058534 |
| PubChem Substance ID: | 24895384 |
Description
| Application | Noncompetitive inhibitor of the chymotrypsin-like activity of the 20S proteasome in vitro. |
| Biochem/physiol Actions | An antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups. |
Properties
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | KB4725000 |
References
| reference | Mullbacher, A., et al. J. Gen. Microbiol. 131, 1251, (1985) Abstract |
| Jones, R.J. and Hancock, J.G. J. Gen. Microbiol. 134, 2067, (1988) | |
| Kroll, M., The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome. Chem. Biol. 10, 689, (1999) | |
| Merck | Merck 13,4454 |
| Beilstein | Beil. 27,IV,8902 |
